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KMID : 0613820070170020192
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Journal of Life Science
2007 Volume.17 No. 2 p.192 ~ p.197
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Role of Rho A and F-actin for uropod formation in T lymphocytes
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Lee Jong-Hwan
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Abstract
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Two distinct morphological features, leading edge and uropod, in mobile T lymphocyte are crucial for efficient directional movement. The uropod is a unique rear protrusion in migrating lymphocytes, in which several proteins, including CD44, ERM (ezrin/radixin/moesin), and F-actin cytoskeleton are concentrated and concerted. F-actin cytoskeleton is a basic mold for the shape maintenance. Rho A small GTPase acts as cytoskeleton organizer. So far, various pathways potentially can induce the Rho activation. PDZ domain is able to increase active Rho A form (Rho-GTP) level, reorganize F-actin cytoskeleton, disrupts the uropod structure and cell migration was diminished, suggesting that signaling pathways between Rho and F-actin cytoskeleton are related to uropod formation.
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KEYWORD
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Uropod, Rho A, F-atctin, migration, PDZ
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